Wilkes-Barre is a city in Luzerne County, Pennsylvania, United States, and its county seat. Located along the Susquehanna River in Northeastern Pennsylvania, it had a population of 44,328 in the 2020 census. It is part of the Wyoming Valley metropolitan area, which includes five cities and more than 40 boroughs forming a contiguous urban corridor with an estimated 574,000 residents. Wilkes-Barre is located 49 miles (79 km) north-northwest of Allentown, 97 miles (156 km) north-northwest of Philadelphia, and 106 miles (171 km) west-northwest of New York City.