The Upstate Medical University Arena is a multi-purpose arena located in Syracuse, New York. It is part of the Oncenter Complex. Designed by Edgarton and Edgarton and built from 1949 through 1951, the structure is significant as an example of a World War I, World War II and Aroostook War commemorative and as "an early and sophisticated example of single-span thin-shell concrete roof construction." It was listed on the National Register of Historic Places in 1988. The Upstate Medical University Arena has been renovated twice, in 1994 and 2018.