Simpsonville is a city in Greenville County, South Carolina, United States. It is part of the Greenville, SC Metropolitan Statistical Area. The population is 23,354, according to the 2020 census, up from 18,238 in the 2010 census. The city's 2024 Annual Financial Audit estimates the population to be about 27,500. Independent data site DataCommons estimates the population of Simpsonville to be about 28,078. Simpsonville is part of the "Golden Strip", along with the cities of Mauldin and Fountain Inn, an area which is noted for having low unemployment due to a diversity of industries that include H.B. Fuller, KEMET, Sealed Air and Milliken. The unemployment rate is about 3.1 percent, according to 2023 census estimates. It is the 23rd-most populous city in South Carolina.