St. Louis is an independent city in the U.S. state of Missouri. It lies near the confluence of the Mississippi and the Missouri rivers. In 2020, the city proper had a population of 301,578, while its metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million. It is the largest metropolitan area in Missouri and the second-largest in Illinois. The city's combined statistical area is the 20th-largest in the United States.