Saginaw is a city in Saginaw County, Michigan, United States, and its county seat. It had a population of 44,202 at the 2020 census. Located along the Saginaw River, Saginaw is adjacent to Saginaw Charter Township and considered part of Greater Tri-Cities region of Central Michigan. The Saginaw metropolitan area had a population of 190,124 in 2020, while the Tri-Cities area had 377,474 residents.