House of Blues is an American chain of live music concert halls and restaurants. It was founded by Isaac Tigrett, the co-founder of Hard Rock Cafe, and Dan Aykroyd, co-star of the 1980 film The Blues Brothers. The first location opened at Harvard Square in Cambridge, Massachusetts, on November 26, 1992. The chain has been a division of Live Nation Entertainment since July 2006, and there are 11 locations throughout the United States as of 2025.