The Fox Cities are a group of communities located along the Fox River in east-central Wisconsin. The region centers around the city of Appleton and includes other core municipalities such as Neenah, Menasha, Kaukauna, Grand Chute, and Fox Crossing. These cities are situated in Outagamie, Winnebago, and Calumet counties and have historically developed due to their proximity to the river, which played a significant role in transportation and industrial growth, particularly in paper manufacturing.