Kain may refer to:
- Kain
- Kain (surname)
- Kain Department, a department in the Yatenga Province of Burkina Faso
- Mount Kain, a mountain in the Fraser River Valley of Mount Robson Provincial Park, Canada
- Kaïn, a folk rock group from Quebec
- Kain , the protagonist of the Legacy of Kain series of videogames
- Kain , a character from Tenchi Muyo! in Love
- Kain, an archetype in Fire Emblem
- Kain, a former municipality part of Tournai, Belgium
- KAIN-LP, a defunct low-power television station formerly licensed to Natchitoches, Louisiana, United States
- A former name for Qaen, Iran
- Kain panjang, a traditional cloth from Indonesia, often patterned with batik or ikat'
- Kain the Dragoon from Final Fantasy IV.
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