Kain may refer to:

• Kain
• Kain (surname)
• Kain Department, a department in the Yatenga Province of Burkina Faso
• Mount Kain, a mountain in the Fraser River Valley of Mount Robson Provincial Park, Canada
• Kaïn, a folk rock group from Quebec
• Kain , the protagonist of the Legacy of Kain series of videogames
• Kain , a character from Tenchi Muyo! in Love
• Kain, an archetype in Fire Emblem
• Kain, a former municipality part of Tournai, Belgium
• KAIN-LP, a defunct low-power television station formerly licensed to Natchitoches, Louisiana, United States
• A former name for Qaen, Iran
• Kain panjang, a traditional cloth from Indonesia, often patterned with batik or ikat'
• Kain the Dragoon from Final Fantasy IV.