The High Point Panthers men's lacrosse team is a college lacrosse team that represents High Point University in High Point, North Carolina, United States. The school's teams are typically members of the Big South Conference, but due to the Big South not sponsoring Men's lacrosse, the HPU men's lacrosse team has had to play as associate members of other conferences. It had played in the Atlantic Sun Conference, now known as the ASUN Conference, in the 2014 season, moving to the Southern Conference (SoCon) after that season when the SoCon took over operation of the ASUN men's lacrosse league. The Panthers remained in SoCon men's lacrosse through the 2022 season, after which they moved men's lacrosse to the newly established league of the Atlantic 10 Conference (A-10).