Compete 4 Cause Classic

The 2021–22 USC Trojans men's basketball team represented the University of Southern California during the 2021–22 NCAA Division I men's basketball season. The Trojans are led by 9th-year head coach Andy Enfield and played their home games at the Galen Center for the 16th season in Los Angeles as members of the Pac-12 Conference. They finished the season 26–8, 14–6 in Pac-12 Play to finish in third place. As the No. 3 seed in the Pac-12 tournament, they defeated Washington in the quarterfinals before losing in the semifinals to UCLA. They received an at-large bid to the NCAA tournament as the No. 7 seed in the Midwest Region, where they lost in the First Round to Miami (FL).