Bob or Bobby James may refer to:

• Bob James (sailor) (1933–2016), American sailor
• Bob James (musician), American jazz keyboardist, arranger and producer
• Bob James (baseball), former baseball player for the Expos, Tigers, and White Sox
• Bob James (1952–2021), American singer, frontman of Montrose, 1974–76
• Bob James, English singer, former representative of CMT Europe, 1995–97
• Bob James, saxophonist and guitar player for British progressive rock band Skin Alley
• Bobby James, American football coach
• Bobby James, a song from the 2001 N.E.R.D. album In Search of...